rac-N-[Hydroxy(4-pyridyl)methyl]picolinamide: a hemiamidal

rac-N-[Hydroxy(4-pyridyl)methyl]picolinamide: a hemiamidal

Blog Article

The title compound, C12H11N3O2, a hemiamidal, was synthesized by solvent-free aldol condensation at room temperature by grinding picolinamide with isonicotinaldehyde in a 1:1 molar ratio.In the molecule, the two pyridine rings are inclined to one another by 58.75 (6)°.They are linked, at positions 2 and 4, by the hemiamidal bridge (–CO—NH—CHOH–).The NH-group H atom forms an intramolecular hydrogen bond with the N atom of the picolinamide pyridine ring.

In the crystal, symmetry-related molecules elliot pecan tree for sale are linked via N—H.O hydrogen bonds, involving the NH group H atom caruso milk thistle of the hemiamidal bridge and the hydroxy O atom, forming inversion-related dimers, with graph-set R22(8).Adjacent molecules are also linked via O—H.N hydrogen bonds, involving the hydroxy substituent and the 4-pyridine N atom.Together these interactions lead to the formation of double-stranded ribbon-like hydrogen-bonded polymers propagating in [010].

The latter are further connected via C—H.O hydrogen bonds involving the carbonyl O atom, so forming a two-dimensional network in (011).